twocats ranjit Thank you for helping. Basically, you both give the same tip with different words. I tried it and lifted my hands higher up. @twocats posted good pictures how it should look like. The pictures are very useful, because our hands are about the same size.
Unfortunately, it doesn't increase the comfort. It is a similar tension in the wrist, but still worse than what I do currently. I think the reason for this is, it needs a greater spread between thumb and index finger.
Just by looking at the angled picture, the thumb presses B from the top, because of small hands, the thumb goes down diagonal, coming over from the C. But it is not allowed to press the C down. This means the thumb has to touch the B away from the C, basically in the center of the key.
With my approach, my thumb can be a little bit closer to C, because it passes C where no C-key is. On top of that, this approach requires less (clockwise) rotation of the wrist. The difference isn't much between both approaches, but the key-end approach is indeed a tad better. No matter how often I compare both, my hand feels a bit more relaxed this way.
twocats Not sure if you saw my comment, but I have small hands (can easily play an octave, a 9th only situationally) and raising my wrist high eliminates a lot of the rotation and makes the chord reasonably comfortable for me.
I am sure, you would be comfortable with the key-end approach as well. Since a few weeks I have an issue, maybe an inflammation somewhere in my RH, near the wrist on the outer side (pinky side). This makes me to feel some pain at certain grips, that shouldn't be a problem normally.