I'm generally very sensitive to changes at the register breaks but I've mostly made musical peace with it.
On acoustic pianos, people (sales folks or piano tuners or even my teacher) often tell me that they can't hear what I'm hearing... the funny part though is that piano tuners are able to fix the issue even though they can't hear it!
Sometimes a note will sound strange to me on uprights or even hybrid digitals that have a soundboard. In those cases, I found that adjusting the position of the piano helped.